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Rheumatology Advance Access originally published online on June 25, 2008
Rheumatology 2008 47(8):1114-1116; doi:10.1093/rheumatology/ken236
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EDITORIALS

A potential role for synovial fluid mesenchymal stem cells in ligament regeneration

D. McGonagle and E. Jones

The Academic Unit of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK

Correspondence to: D. McGonagle, The Academic Unit of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS7 4SA, UK. E-mail: d.g.mcgonagle@leeds.ac.uk

The first 150 words of the full text of this article appear below.

Joint regeneration in adults

There is clear evidence for spontaneous joint remodelling and repair in man. Following injury various joint structures, including ligament and tendon, go through a fairly classical cascade of acute injury with immobility, subsequent inflammatory responses and finally adaptive repair response [1]. Synovium also has considerable powers of regeneration given its reappearance following surgical synovectomy [2]. Adaptive responses at fracture sites, at regions of weight bearing and osteophytosis attest to the remodelling capabilities of bone [3]. Additionally, cartilage regeneration at sites of osteophytosis is well recognized and even hyaline articular cartilage-like tissue may occur following corrective osteotomies in OA [4] or following subchondral bone microfracture techniques [5].

A better understanding of the pathophysiological basis for these diverse joint remodelling responses could have major implications for future joint repair strategies. The classical paradigm of joint repair involves the concept of a mesenchymal . . . [Full Text of this Article]

A potential role for SF MSCs in joint repair

SF MSCs—beyond the ligament

A move towards in situ tissue engineering


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