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Rheumatology Advance Access originally published online on March 19, 2008
Rheumatology 2008 47(5):617-621; doi:10.1093/rheumatology/ken054
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Associations between gout tophus and polymorphisms 869T/C and –509C/T in transforming growth factor β1 gene

S.-J. Chang1, C.-J. Chen2, F.-C. Tsai3,4, H.-M. Lai2, P.-C. Tsai5, M.-H. Tsai4 and Y.-C. Ko1

1Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Department of Radiology, Long Cyuan Veterans Hospital, PingTung, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung and 5Graduate Institute of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

Correspondence to: S.-J. Chang, Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan. E-mail: changsj{at}kmu.edu.tw


  Abstract

Objectives. To investigate the associations between gout tophus and polymorphisms 869T/C and –509C/T in TGF-β1 gene.

Methods. The polymorphisms 869T/C and –509C/T were determined in 73 gout patients and 114 healthy controls among male Taiwanese using the PCR–restriction fragment length polymorphism method. Each patient was matched with 1–2 controls by age within 1–2 yrs. The tophus number was measured from all the patients’ arms and legs.

Results. Neither 869T/C nor –509C/T showed a significant association between patients and controls in the proportions of genotypes, allele frequency or dominant and recessive models. The mean number of tophi for all patients was 1.53 ± 3.44, showing a significant difference in distribution among the genotypes at polymorphism 869T/C (P = 0.006), but not those in polymorphism –509C/T (P > 0.05). Those carrying genotype CC at polymorphism 869T/C have a mean number of tophi 0.35 (± 1.11), which is significantly lower than those carrying genotype TT (3.73 ± 4.67; P < 0.05). Those with genotype TT at polymorphism 869T/C also had 11.06 times the likelihood of having at least one tophus compared with the genotype CC after adjustment of hyperuricaemia (95% CI = 1.84, 66.36; P = 0.009). However, except for the tophus number, these two polymorphisms did not show any significant association with the clinical characteristics or biochemical markers.

Conclusions. The polymorphism 869T/C in TGF-β1 gene has a significant association with the occurrence of tophus in gout patients.

KEY WORDS: Tophus, TGF, Gout, Polymorphism

Submitted 20 October 2007; revised version accepted 23 January 2008.
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